Up to 9,500 members of the Aslef union have planned strike action for Saturday 26 November.
The latest industrial action follows four previous 24-hour strikes by drivers, which led to train services being cancelled and delayed.
"We regret that passengers will be inconvenienced for another day. We don't want to be taking this action," said Aslef's general secretary Mick Whelan.
The UK rail industry has been hit by a wave of strikes in recent months, with different unions representing different job roles staging walk-outs.
The 12 rail companies involved are:
Avanti West Coast
East Midlands Railway
Great Western Railway
London North Eastern Railway
West Midlands Trains.
The government's minister for the railways, Huw Merriman said the strikes had "cost the railway about half a billion" so far this year.
CT Business Travel highly recommends checking with your rail provider before travelling. We strongly advise that if you are planning to travel to a destination or an airport on those dates that you do not travel by train and find an alternative mode of transport. Please contact the team for support and assistance regarding this.
You can contact a member of the CT Business Travel team on 01892 616122 where we offer 24/7 support.